skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.11d (Release date: 2016-11-28)
SearchBox Top
SearchBox Bottom
Alectinib (Code C101790)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Alectinib

Definition: An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, alectinib binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.

Display Name: Alectinib

Label: Alectinib

NCI Thesaurus Code: C101790 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3640218  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5H-benzo(b)carbazole-3-carbonitrile, 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-(4-(4-morpholinyl)-1-piperidinyl)-11-oxo-
AF-802
AF802
Alecensa
Alectinib
ALECTINIB
CH5424802
RG7853
RO5424802

External Source Codes: 
CAS Registry Number 1256580-46-7 (see NLM ChemIDplus info)
FDA UNII Code LIJ4CT1Z3Y
ChEBI ID CHEBI:62268 (see ChEBI info)
PDQ Closed Trial Search ID 733572
PDQ Open Trial Search ID 733572 (check for NCI PDQ open clinical trial info)
UMLS CUI C3640218

Other Properties:
Name Value (qualifiers indented underneath)
code C101790
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101790

Mainbox Bottom