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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Lipopolysaccharide (Code C101788)

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Terms & Properties

Preferred Name: Lipopolysaccharide

Definition: An endotoxin and biologically active component of the Gram-negative bacterial cell wall that is a Toll-like receptor 4 (TLR4) agonist with potential immunostimulatory activity. Upon internalization, lipopolysaccharide (LPS) activates TLR4 which in turn activates the NFkappaB pathway, in addition to mitogen-activated protein kinases signaling pathways. This leads to the release of proinflammatory cytokines and stimulates an innate immune response against vaccine antigens.

Label: Lipopolysaccharide

NCI Thesaurus Code: C101788 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0023810  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
ChEBI ID CHEBI:16412 (see ChEBI info)
PDQ Closed Trial Search ID 732862
PDQ Open Trial Search ID 732862 (check for NCI PDQ open clinical trial info)
UMLS CUI C0023810

Other Properties:
     Name Value (qualifiers indented underneath)
code C101788
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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