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Version: 17.06d (Release date: 2017-06-26)
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TIL 1383I T Cell Receptor-Transduced Autologous T Cells (Code C101787)

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Terms & Properties

Preferred Name: TIL 1383I T Cell Receptor-Transduced Autologous T Cells

Definition: Autologous peripheral blood lymphocytes-derived T cells transduced with a retroviral encoding TIL 1383I, a T cell receptor (TCR) specific for melanoma antigen tyrosinase, with potential immunostimulating and antineoplastic activity. After transduction, expansion in culture, and reintroduction into the patient, TIL 1383I TCR-transduced autologous T cells bind to tumor cells expressing tyrosinase, which may induce cytokine expression, activation and proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against tyrosinase-expressing tumor cells. TIL 1383I TCR originated from a melanoma patient's CD4+ tumor-infiltrating lymphocytes and is reactive against a class I MHC (HLA-A2)-restricted epitope (368-376) of tyrosinase.

Display Name: TIL 1383I T Cell Receptor-Transduced Autologous T Cells

Label: TIL 1383I T Cell Receptor-Transduced Autologous T Cells

NCI Thesaurus Code: C101787 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435906  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
TIL 1383I TCR Transduced Autologous T Cells
TIL 1383I T Cell Receptor-Transduced Autologous T Cells

External Source Codes: 
PDQ Closed Trial Search ID 732858
PDQ Open Trial Search ID 732858 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435906

Other Properties:
     Name Value (qualifiers indented underneath)
code C101787
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101787

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