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Version: 17.06d (Release date: 2017-06-26)
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Lipegfilgrastim (Code C101778)

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Terms & Properties

Preferred Name: Lipegfilgrastim

Definition: A long acting glyco-pegylated recombinant form of human granulocyte colony-stimulating factor (G-CSF), with hematopoietic activity. Similar to G-CSF, lipegfilgrastim binds to and activates specific cell surface receptors, and stimulates neutrophil progenitor proliferation and differentiation. Therefore, this agent may prevent the duration and incidence of chemotherapy-induced neutropenia. Compared to filgrastim, lipegfilgrastim has a prolonged plasma half-life.

Display Name: Lipegfilgrastim

Label: Lipegfilgrastim

NCI Thesaurus Code: C101778 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3640212  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LIPEFILGRASTIM
Lipegfilgrastim
Lonquest
Pegylated granulocyte colony stimulating factor (human short isoform) O(sup 3.137)-((3,5-dideoxy-5-((N-((omega-methoxypoly(oxyethylene))carbonyl)glycyl)amino)-D- glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-2-(acetylamino)-2-deoxy-alpha-D- galactopyranosyl)-des-(37-39)-(1-methionine)human granulocyte colony-stimulating factor (G-CSF, pluripoietin)
Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-methoxy-, 133-ester with granulocyte colony-stimulating factor (methionyl,133-(O-(2-(acetylamino)-6-O-(N-((N- carboxyglycyl)amino)-alpha-neuraminosyl)-2-deoxy-alpha-D-galactopyranosyl)-L-threonine)) (human)
XM22

External Source Codes: 
CAS Registry Number 1117844-87-7 (see NLM ChemIDplus info)
FDA UNII Code 4AWF0N6QV3
PDQ Closed Trial Search ID 732856
PDQ Open Trial Search ID 732856 (check for NCI PDQ open clinical trial info)
UMLS CUI C3640212

Other Properties:
     Name Value (qualifiers indented underneath)
code C101778
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101778

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