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Version: 17.12d (Release date: 2017-12-26)
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Lipegfilgrastim (Code C101778)

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Terms & Properties

Preferred Name: Lipegfilgrastim

Definition: A long acting glyco-pegylated recombinant form of human granulocyte colony-stimulating factor (G-CSF), with hematopoietic activity. Similar to G-CSF, lipegfilgrastim binds to and activates specific cell surface receptors, and stimulates neutrophil progenitor proliferation and differentiation. Therefore, this agent may prevent the duration and incidence of chemotherapy-induced neutropenia. Compared to filgrastim, lipegfilgrastim has a prolonged plasma half-life.

Display Name: Lipegfilgrastim

Label: Lipegfilgrastim

NCI Thesaurus Code: C101778 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3640212  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Pegylated granulocyte colony stimulating factor (human short isoform) O(sup 3.137)-((3,5-dideoxy-5-((N-((omega-methoxypoly(oxyethylene))carbonyl)glycyl)amino)-D- glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-2-(acetylamino)-2-deoxy-alpha-D- galactopyranosyl)-des-(37-39)-(1-methionine)human granulocyte colony-stimulating factor (G-CSF, pluripoietin)
Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-methoxy-, 133-ester with granulocyte colony-stimulating factor (methionyl,133-(O-(2-(acetylamino)-6-O-(N-((N- carboxyglycyl)amino)-alpha-neuraminosyl)-2-deoxy-alpha-D-galactopyranosyl)-L-threonine)) (human)

External Source Codes: 
CAS Registry Number 1117844-87-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 732856
PDQ Open Trial Search ID 732856 (check for NCI PDQ open clinical trial info)
UMLS CUI C3640212

Other Properties:
     Name Value (qualifiers indented underneath)
code C101778
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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