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Version: 17.06d (Release date: 2017-06-26)
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Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes (Code C101773)

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Terms & Properties

Preferred Name: Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes

Definition: A preparation of peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell chimeric antigen receptor (CAR) specific for mesothelin with potential immunostimulatory and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, the mesothelin-specific chimeric antigen receptor-engineered PBLs bind to tumor cells expressing mesothelin. This may stimulate the secretion of cytokines and result in cell lysis of mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers.

Display Name: Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes

Label: Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes

NCI Thesaurus Code: C101773 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435898  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-mesothelin CAR PBL
Mesothelin-specific Chimeric Antigen Receptor-engineered Peripheral Blood Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 732671
PDQ Open Trial Search ID 732671 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435898

Other Properties:
     Name Value (qualifiers indented underneath)
code C101773
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101773

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