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Version: 17.06d (Release date: 2017-06-26)
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MEK Inhibitor WX-554 (Code C101532)

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Terms & Properties

Preferred Name: MEK Inhibitor WX-554

Definition: An orally available small molecule mitogen-activated protein kinase kinase (MAP2K, MAPK/ERK kinase, or MEK) inhibitor, with potential antineoplastic activity. MEK inhibitor WX-554 selectively binds to and inhibits the activity of MEK, thereby preventing the activation of MEK-dependent effector proteins including some transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK, a dual-specificity threonine/tyrosine kinase that plays a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway, is frequently upregulated in a variety of tumor cell types.

Label: MEK Inhibitor WX-554

NCI Thesaurus Code: C101532 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435784  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MEK Inhibitor WX-554
WX-554

External Source Codes: 
PDQ Closed Trial Search ID 732484
PDQ Open Trial Search ID 732484 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435784

Other Properties:
     Name Value (qualifiers indented underneath)
code C101532
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101532

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