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Version: 17.06d (Release date: 2017-06-26)
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Hypoxia-activated Prodrug TH-4000 (Code C101523)

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Terms & Properties

Preferred Name: Hypoxia-activated Prodrug TH-4000

Definition: A proprietary, hypoxia-activated prodrug with potential antineoplastic activity. Upon administration, the hypoxia-activated prodrug TH-4000 is activated in the hypoxic cells within tumors into an irreversible pan-HER inhibitor via a mechanism of action not yet fully elucidated. As a result, this agent inhibits cellular proliferation and differentiation of tumor cells overexpressing HER kinases, which belong to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. Healthy, normal tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity.

Display Name: Hypoxia-activated Prodrug TH-4000

Label: Hypoxia-activated Prodrug TH-4000

NCI Thesaurus Code: C101523 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435780  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hypoxia-activated Prodrug TH-4000
Hypoxin
PR610
TH-4000

External Source Codes: 
PDQ Closed Trial Search ID 732241
PDQ Open Trial Search ID 732241 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435780

Other Properties:
     Name Value (qualifiers indented underneath)
code C101523
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101523

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