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Version: 17.06d (Release date: 2017-06-26)
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FLT3/KIT Kinase Inhibitor AKN-028 (Code C101520)

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Terms & Properties

Preferred Name: FLT3/KIT Kinase Inhibitor AKN-028

Definition: An orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases.

Label: FLT3/KIT Kinase Inhibitor AKN-028

NCI Thesaurus Code: C101520 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3852612  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AKN-028
BVT-II
FLT3/KIT Kinase Inhibitor AKN-028

External Source Codes: 
PDQ Closed Trial Search ID 731885
PDQ Open Trial Search ID 731885 (check for NCI PDQ open clinical trial info)
UMLS CUI C3852612

Other Properties:
     Name Value (qualifiers indented underneath)
code C101520
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101520

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