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Version: 17.06d (Release date: 2017-06-26)
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FMS Inhibitor JNJ-40346527 (Code C101519)

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Terms & Properties

Preferred Name: FMS Inhibitor JNJ-40346527

Definition: A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS can not activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells. FMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation, recruitment, and activation as well as the regulation of cell proliferation.

Label: FMS Inhibitor JNJ-40346527

NCI Thesaurus Code: C101519 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3640124  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FMS Inhibitor JNJ-40346527
JNJ-40346527

External Source Codes: 
PDQ Closed Trial Search ID 730665
PDQ Open Trial Search ID 730665 (check for NCI PDQ open clinical trial info)
UMLS CUI C3640124

Other Properties:
     Name Value (qualifiers indented underneath)
code C101519
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101519

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