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Version: 17.06d (Release date: 2017-06-26)
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Gamma-delta Tocotrienol (Code C101517)

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Terms & Properties

Preferred Name: Gamma-delta Tocotrienol

Definition: An orally available nutritional supplement containing the gamma and delta forms of the vitamin E family member tocotrienol, with hypocholesterolemic, antithrombotic, antioxidant, and potential antineoplastic activity. Upon oral administration, gamma-delta tocotrienol accumulates in cancer cells and may exert their anti-cancer activity in part through 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase downregulation and/or degradation, cell cycle arrest, and induction of caspase-mediated apoptosis. In addition, this agent may inhibit angiogenesis partially through the blockage of vascular endothelial growth factor receptor (VEGFR) and the inhibition of tumor cell-induced vessel formation. Altogether, this may result in the inhibition of tumor cell growth. Further, this agent prevents free radical formation and inhibits lipid peroxidation. Tocotrienols contain 3 double bonds, absent in tocopherols, on its farnesyl isoprenoid side chain that likely contribute to its anti-cancer activities.

Label: Gamma-delta Tocotrienol

NCI Thesaurus Code: C101517 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435774  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gamma-delta Tocotrienol

External Source Codes: 
PDQ Closed Trial Search ID 730661
PDQ Open Trial Search ID 730661 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C101517
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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