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Version: 16.10e (Release date: 2016-10-31)
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Verteporfin (Code C1014)

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Terms & Properties

Preferred Name: Verteporfin

Definition: A synthetic light-activated agent with photodynamic activity. Upon systemic administration, verteporfin accumulates in neovessels in the eye and, once stimulated by nonthermal red light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to neovascular endothelium and blood vessel occlusion. (NCI04)

Label: Verteporfin

NCI Thesaurus Code: C1014 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0387288  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzoporphyrin Derivative Monoacid Ring A
BPD-MA
VERTEPORFIN
Verteporfin
Visudyne

External Source Codes: 
CAS Registry Number 129497-78-5 (see NLM ChemIDplus info)
FDA UNII Code 0X9PA28K43
ChEBI ID CHEBI:32293 (see ChEBI info)
PDQ Closed Trial Search ID 42130
PDQ Open Trial Search ID 42130 (check for NCI PDQ open clinical trial info)
UMLS CUI C0387288

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Photosensitizer, subfoveal choroidal neovascularization
code C1014
Contributing_Source FDA
Legacy_Concept_Name Verteporfin
Semantic_Type Biologically Active Substance
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1014

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