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Version: 16.11d (Release date: 2016-11-28)
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STAT3 Antisense Oligonucleotide ISIS 481464 (Code C101368)

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Terms & Properties

Preferred Name: STAT3 Antisense Oligonucleotide ISIS 481464

Definition: An antisense oligonucleotide targeting signal transducer and activator of transcription 3 (STAT3) with potential antitumor activity. STAT3 antisense oligonucleotide ISIS 481464 binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth. STAT3, a protein overexpressed in a variety of human cancers, plays a critical role in tumor cell growth and survival.

Display Name: STAT3 Antisense Oligonucleotide ISIS 481464

Label: STAT3 Antisense Oligonucleotide ISIS 481464

NCI Thesaurus Code: C101368 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435548  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD9150
ISIS-STAT3rx
ISIS 481464
STAT3 Antisense Oligonucleotide ISIS 481464

External Source Codes: 
PDQ Closed Trial Search ID 729992
PDQ Open Trial Search ID 729992 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435548

Other Properties:
Name Value (qualifiers indented underneath)
code C101368
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101368

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