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Version: 17.06d (Release date: 2017-06-26)
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CD-expressing Bifidobacterium APS001F (Code C101367)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: CD-expressing Bifidobacterium APS001F

Definition: A recombinant anaerobic bacterium, Bifidobacterium longum, encoding the cytosine deaminase (CD) gene with potential antineoplastic adjuvant activity. Upon injection, the CD-expressing bifidobacterium preferentially localizes and grows in the hypoxic environment of the tumor and expresses CD, an enzyme that catalyzes the intracellular conversion of the prodrug flucytosine (5-FC) into the antineoplastic agent 5-fluorouracil (5-FU). Upon administration of 5-FC, and subsequent localized conversion into 5-FU and its cytotoxic active metabolites, the tumor is specifically exposed to cytotoxic agents while the exposure to normal tissues is minimal.

Display Name: CD-expressing Bifidobacterium APS001F

Label: CD-expressing Bifidobacterium APS001F

NCI Thesaurus Code: C101367 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435547  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
APS001F
CD-expressing Bifidobacterium APS001F

External Source Codes: 
PDQ Closed Trial Search ID 729923
PDQ Open Trial Search ID 729923 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435547

Other Properties:
     Name Value (qualifiers indented underneath)
code C101367
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101367

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