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Version: 17.06d (Release date: 2017-06-26)
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Liposomal MUC1/PET-lipid A Vaccine (Code C101262)

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Terms & Properties

Preferred Name: Liposomal MUC1/PET-lipid A Vaccine

Definition: A cancer vaccine comprised of a 43 amino acid epitope from glycoprotein MUC1 (mucin 1) and the synthetic Toll-like receptor 4 (TLR-4) agonist PET lipid A encapsulated in cholesterol/dipalmitoylphosphatidylcholine (DPPC)/dimyristoylphosphatidylglycerol (DMPG) liposomes, with potential immunostimulatory and antineoplastic activities. The MUC1 epitope is composed of two 20 amino glycosylated VNTR (various number tandem repeats) from human MUC1A and including 6 glycosylated sites modified by Tn (alfa-N-acetyl-D-galactosamine). Immunization of liposomal MUC1/PET-lipid A vaccine results in an antibody as well as a cytotoxic T-lymphocyte (CTL) response against hypoglycosylated MUC1 expressing tumor cells. The tumor associated antigen MUC1, a type I transmembrane protein, is overexpressed and aberrantly glycosylated in a variety of tumor cells. As a vaccine adjuvant, PET lipid A, also known as penta erythritol lipid A, stimulates both cellular and humoral responses to the vaccine antigen.

Label: Liposomal MUC1/PET-lipid A Vaccine

NCI Thesaurus Code: C101262 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435510  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Liposomal MUC1/PET-lipid A Vaccine
ONT-10

External Source Codes: 
PDQ Closed Trial Search ID 729635
PDQ Open Trial Search ID 729635 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435510

Other Properties:
     Name Value (qualifiers indented underneath)
code C101262
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101262

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