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Version: 17.06d (Release date: 2017-06-26)
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Pegylated Recombinant L-asparaginase Erwinia chrysanthemi (Code C101259)

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Terms & Properties

Preferred Name: Pegylated Recombinant L-asparaginase Erwinia chrysanthemi

Definition: A pegylated, recombinant form of L-asparaginase derived from the bacterium Erwinia chrysanthemi (mPEG-R-Crisantaspase), with potential antineoplastic activity. Upon intravenous administration of pegylated recombinant L-asparaginase Erwinia chrysanthemi, asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting cancer cells of asparagine thus blocking protein synthesis and tumor cell proliferation. Asparagine is critical to protein synthesis in cancer cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Compared to other available Erwinia chrysanthemi derived L-asparaginase agents, the pegylated form is longer acting and less immunogenic.

Label: Pegylated Recombinant L-asparaginase Erwinia chrysanthemi

NCI Thesaurus Code: C101259 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435507  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Asparec
mPEG-R-crisantaspase
Pegylated Recombinant L-asparaginase Erwinia chrysanthemi

External Source Codes: 
PDQ Closed Trial Search ID 729150
PDQ Open Trial Search ID 729150 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435507

Other Properties:
     Name Value (qualifiers indented underneath)
code C101259
Semantic_Type Enzyme
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101259

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