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Version: 17.06d (Release date: 2017-06-26)
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CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells (Code C101258)

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Terms & Properties

Preferred Name: CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells

Definition: Allogeneic T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-4-1BB-expressing allogeneic T-lymphocyte cells direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19 and the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.

Display Name: CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells

Label: CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells

NCI Thesaurus Code: C101258 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435506  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CART-19 Cells
CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells

External Source Codes: 
PDQ Closed Trial Search ID 729149
PDQ Open Trial Search ID 729149 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435506

Other Properties:
     Name Value (qualifiers indented underneath)
code C101258
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101258

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