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Version: 17.06d (Release date: 2017-06-26)
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IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells (Code C101257)

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Terms & Properties

Preferred Name: IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells

Definition: Autologous glioma cells treated ex vivo with an 18-mer antisense oligodeoxynucleotide of insulin-like growth factor receptor 1 (IGF-1R/AS ODN), with potential antineoplastic activity. IGF-1R/AS ODN pre-treated glioma cells encapsulated in small Lucite diffusion chambers are implanted into a subcutaneous pocket in the patient's abdominal rectus sheath. Within the diffusion chambers, IGF-1R/AS ODN binds to IGF-1R mRNA, and shuts down the translation of IGF-1R in the glioma cells. Downregulation of IGF-1R induces apoptosis and causes the release of exosomes, which contain tumor-associated antigens (TAAs). The diffusion of exosomes and IGF-1R/AS ODN from the Lucite chambers may active the patient's immune system and mount a cytotoxic T-lymphocyte (CTL) response against cells expressing these TAAs. IGF-1R, a receptor tyrosine kinase, is overexpressed in a variety of tumor cell types and is essential for tumor cell growth, transformation and survival.

Display Name: IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells

Label: IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells

NCI Thesaurus Code: C101257 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435505  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IGF-1R/AS ODN-treated Autologous Glioma Cells
IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells

External Source Codes: 
PDQ Closed Trial Search ID 729046
PDQ Open Trial Search ID 729046 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435505

Other Properties:
     Name Value (qualifiers indented underneath)
code C101257
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101257

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