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Version: 17.12d (Release date: 2017-12-26)
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Hsp90 Inhibitor PU-H71 (Code C101227)

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Terms & Properties

Preferred Name: Hsp90 Inhibitor PU-H71

Definition: A purine-based heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor PU-H71 specifically inhibits active Hsp90, thereby inhibiting its chaperone function and promoting the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may result in the inhibition of cellular proliferation in susceptible tumor cell populations. Hsp90, a molecular chaperone protein, is upregulated in a variety of tumor cell types.

Display Name: Hsp90 Inhibitor PU-H71

Label: Hsp90 Inhibitor PU-H71

NCI Thesaurus Code: C101227 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3502086  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9H-Purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)-
Hsp90 Inhibitor PU-H71

External Source Codes: 
CAS Registry Number 873436-91-0 (see NLM ChemIDplus info)
FDA UNII Code 06IVK87M04
PDQ Closed Trial Search ID 732547
PDQ Open Trial Search ID 732547 (check for NCI PDQ open clinical trial info)
UMLS CUI C3502086

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H21IN6O2S
code C101227
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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