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Version: 16.10e (Release date: 2016-10-31)
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Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591 (Code C101133)

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Terms & Properties

Preferred Name: Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591

Definition: A radioimmunoconjugate comprised of the recombinant humanized monoclonal antibody J591 against prostate-specific membrane antigen (PSMA) conjugated to chelator desferrioxamine B (DFO-B) and labeled with the radioisotope zirconium Zr 89 with potential imaging property used in positron emission tomography (PET) imaging. Upon administration of zirconium Zr 89 desferrioxamine B monoclonal antibody huJ591, the antibody moiety binds to the extracellular domain of PSMA, and the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of PSMA-expressing tumor cells. PSMA, or folate hydrolase, is a cell surface peptidase highly expressed by malignant prostate epithelial cells and vascular endothelial cells of numerous solid tumor malignancies. In addition, upon PET imaging this agent provides high tumor:background tissue ratios.

Display Name: Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591

Label: Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591

NCI Thesaurus Code: C101133 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433986  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
89Zr-DFO-huJ591
Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591

External Source Codes: 
PDQ Closed Trial Search ID 728672
PDQ Open Trial Search ID 728672 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433986

Other Properties:
Name Value (qualifiers indented underneath)
code C101133
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101133

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