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Version: 17.06d (Release date: 2017-06-26)
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Elsiglutide (Code C101131)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Elsiglutide

Definition: A synthetic glucagon-like peptide-2 (GLP-2) analogue with potential antidiarrheal and intestinotrophic activities. Upon subcutaneous administration, elsiglutide, a 39 amino acid polypeptide, binds to GLP-2 receptors and thereby promotes proliferation of epithelial cells. Regeneration of endothelial cells damaged during chemotherapy may prevent or decrease chemotherapy-induced diarrhea. In addition, elsiglutide may prevent chemotherapy-induced intestinal injury. GLP-2, a peptide hormone primarily produced in the small intestines in response to food, plays a key role in intestinal epithelial growth, metabolism and regeneration of epithelial cells.

Label: Elsiglutide

NCI Thesaurus Code: C101131 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433984  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Elsiglutide
ELSIGLUTIDE
ZP1846

External Source Codes: 
FDA UNII Code SC864Q40VB
PDQ Closed Trial Search ID 728622
PDQ Open Trial Search ID 728622 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433984

Other Properties:
     Name Value (qualifiers indented underneath)
code C101131
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101131

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