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Version: 16.11d (Release date: 2016-11-28)
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Ammonium Trichlorotellurate (Code C1006)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ammonium Trichlorotellurate

Definition: A synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immunostimulatory and anti-hair loss properties. Ammonium trichlorotellurate induces production of colony stimulating factor (CSF), interleukin-2 (IL-2), and IL-2 receptors by increasing the calcium ion influx through the cell membrane and subsequently exerts its immunostimulatory effects through the CSF-mediated increase in macrophage/granulocytes. This agent is also a potent inducer of interferon and a spectrum of cytokines such as IL-1, IL-6, and tumor necrosis factor (TNF). In animal studies, ammonium trichlorotellurate exerts its anti-hair loss effect by inducing anagen and obstructing spontaneous catagen via promoting follicular keratinocyte proliferation and interfering with terminal differentiation, respectively.

Label: Ammonium Trichlorotellurate

NCI Thesaurus Code: C1006 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1706673  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ammonium Trichlorotellurate
AS-101
IVX-Q-101
Ossirene
Tellurate(1-), trichloro[1,2-ethanediolato(2-)-kappa-O,kappa-O']-,ammonium, (SP-5-22)-

External Source Codes: 
CAS Registry Number 106566-58-9 (see NLM ChemIDplus info)
NSC Code 618654 (see NCI DTP info)
PDQ Closed Trial Search ID 41938
PDQ Open Trial Search ID 41938 (check for NCI PDQ open clinical trial info)
UMLS CUI C1706673

Other Properties:
Name Value (qualifiers indented underneath)
code C1006
DesignNote Although its CN is AS101, it's not the same as 4-Arsanilic acid, NSC 2023, (C29883).
Legacy_Concept_Name Ossirene
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1006

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