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Version: 17.08d (Release date: 2017-08-28)
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Arsenic Trioxide (Code C1005)

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Terms & Properties

Preferred Name: Arsenic Trioxide

Definition: A small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic. (NCI04)

NCI-GLOSS Definition: A drug used to treat acute promyelocytic leukemia (APL) that has not gotten better or that has come back after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer.

Display Name: Arsenic Trioxide

Label: Arsenic Trioxide

NCI Thesaurus Code: C1005 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0052416  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Arsenic (III) Oxide
Arsenic Sesquioxide
Arsenic Trioxide
arsenic trioxide
Arsenous Acid
Arsenous Acid Anhydride
Arsenous Oxide
White Arsenic

External Source Codes: 
CAS Registry Number 1327-53-3 (see NLM ChemIDplus info)
ChEBI ID CHEBI:30621 (see ChEBI info)
NSC Code 706363 (see NCI DTP info)
PDQ Closed Trial Search ID 43067
PDQ Open Trial Search ID 43067 (check for NCI PDQ open clinical trial info)
UMLS CUI C0052416

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Myelodysplastic syndrome; multiple myeloma; chronic myeloid leukemia; acute myelocytic leukemia
Chemical_Formula As2O3
code C1005
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Arsenic_Trioxide
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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