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Version: 17.06d (Release date: 2017-06-26)
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HPV E1/E2 Interaction Inhibitor Gel AP611074 (Code C100100)

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Terms & Properties

Preferred Name: HPV E1/E2 Interaction Inhibitor Gel AP611074

Definition: A topical gel composed of a human papillomavirus (HPV) E1/E2 protein:protein interaction (PPI) inhibitor with potential antiviral activity. Upon topical application of AP611074, this agent prevents binding of the HPV viral proteins E1 to E2, thereby preventing viral DNA replication and growth of HPV. This inhibits viral proliferation and may prevent the formation of anogenital warts caused by HPV. The HPV proteins E1 and E2 are essential for HPV viral replication.

Label: HPV E1/E2 Interaction Inhibitor Gel AP611074

NCI Thesaurus Code: C100100 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433976  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AP611074
HPV E1/E2 Interaction Inhibitor Gel AP611074
PPI inhibitor AP611074
Protein/Protein Interaction Inhibitor AP611074

External Source Codes: 
PDQ Closed Trial Search ID 726615
PDQ Open Trial Search ID 726615 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433976

Other Properties:
     Name Value (qualifiers indented underneath)
code C100100
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C100100

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