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Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells (Code C99215)

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Terms & Properties

Preferred Name: Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells

Definition: A preparation of allogeneic Epstein-Barr virus (EBV)- and human cytomegalovirus (CMV)-specific CD8+ central memory-derived T effector-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating, anti-viral and antineoplastic activities. Upon infusion, allogeneic CD19-specific CAR-modified CD8+ central memory-derived virus-specific T cells directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells which may eventually result in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The viral specific T-cells exert antiviral immunity.

Label: Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells

NCI Thesaurus Code: C99215 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL433046  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells
Allogeneic CD19CAR-TCM Cells

External Source Codes: 
NCI META CUI CL433046 (see NCI Metathesaurus info)
PDQ Closed Trial Search ID 717909 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 717909 (check for NCI PDQ open clinical trial info)

Other Properties:
code C99215
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C99215&ns=NCI_Thesaurus

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