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Version: 14.12e (Release date: 2014-12-29-08:00)
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18F-labeled Mini-PEG Spacered RGD Dimer (Code C97334)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: 18F-labeled Mini-PEG Spacered RGD Dimer

Definition: A radiotracer containing a pegylated dimeric Arg-Gly-Asp (RGD) peptide (NH2-mini-PEG-E[c(RGDyK)]2 or PRGD2) radiolabeled with fluorine 18F-fluorobenzoate (18F-FB), with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET). Upon administration, the RGD moiety of 18F-labeled Mini-PEG Spacered RGD Dimer (18F-FPRGD2) binds to alphaVbeta3 integrin. Upon PET, alphaVbeta3-expressing tumor cells can be visualized and the degree of tumor angiogenesis can be determined. This agent exhibits increased integrin receptor binding affinity, tumor cell uptake and increased radiolabeling yield as compared to the non-pegylated form (18F-FRGD2). Integrins, transmembrane glycoproteins, may be upregulated on proliferating tumor vessel endothelial cells and various cancer cells; their overexpression has been associated with neovascularization, differentiation, proliferation of tumor cells, metastasis and an overall poor prognosis.

Label: 18F-labeled Mini-PEG Spacered RGD Dimer

NCI Thesaurus Code: C97334 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL429825  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(18)F-FB-mini-PEG-E[c(RGDyK)](2)
18F-FPRGD2
18F-labeled Mini-PEG Spacered RGD Dimer
[18F] FPRGD2

External Source Codes: 
NCI META CUI CL429825 (see NCI Metathesaurus info)
PDQ Closed Trial Search ID 703211 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 703211 (check for NCI PDQ open clinical trial info)

Other Properties:
code C97334
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C97334&ns=NCI_Thesaurus

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