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Version: 14.12e (Release date: 2014-12-29-08:00)
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HDAC Inhibitor 4SC-202 (Code C96797)

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Terms & Properties

Preferred Name: HDAC Inhibitor 4SC-202

Definition: An orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor suppressor protein-mediated inhibition of tumor cell division and eventually the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins.

Label: HDAC Inhibitor 4SC-202

NCI Thesaurus Code: C96797 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL429405  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4SC-202
HDAC Inhibitor 4SC-202

External Source Codes: 
NCI META CUI CL429405 (see NCI Metathesaurus info)
PDQ Closed Trial Search ID 700110 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 700110 (check for NCI PDQ open clinical trial info)

Other Properties:
code C96797
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C96797&ns=NCI_Thesaurus

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