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DNA Interference Oligonucleotide PNT2258 (Code C92588)

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Terms & Properties

Preferred Name: DNA Interference Oligonucleotide PNT2258

Definition: A liposomal formulation of the 24-mer oligonucleotide PNT100, with potential antineoplastic activity. PNT2258 targets and complements to untranscribed DNA sequence upstream of BCL2 promoters, thereby interfering with DNA replication and transcription of the BCL2 gene. This may promote and restore the apoptotic pathway in BCL2-overexpressing tumor cells. BCL2, an anti-apoptotic protein, is overexpressed in a wide variety of tumors.

Label: DNA Interference Oligonucleotide PNT2258

NCI Thesaurus Code: C92588 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL423835  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DNAi Drug PNT2258
DNA Interference Oligonucleotide PNT2258
PNT2258

External Source Codes: 
NCI META CUI CL423835 (see NCI Metathesaurus info)
PDQ Closed Trial Search ID 685213 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 685213 (check for NCI PDQ open clinical trial info)

Other Properties:
code C92588
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C92588&ns=NCI_Thesaurus

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