skip navigation links
National Cancer Institute National Cancer Institute U.S. National Institutes of Health www.cancer.gov
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 14.12e (Release date: 2014-12-29-08:00)
SearchBox Top
SearchBox Bottom
Oprozomib (Code C91388)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oprozomib

Definition: An orally bioavailable proteasome inhibitor with potential antineoplastic activity. Proteasome inhibitor ONX 0912 inhibits the activity of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome; this may result in an accumulation of unwanted or misfolded proteins. Disruption of various cell signaling pathways may follow, eventually leading to the induction of apoptosis and inhibition of tumor growth. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated.

Display Name: Oprozomib

Label: Oprozomib

NCI Thesaurus Code: C91388 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
O-methyl-N-((2-methylthiazol-5-yl)carbonyl)-l-seryl-O-methyl-N-((1S)-1-benzyl-2-((2R)-2-methyloxiran-2-yl)-2-oxoethyl)-l-serinamide
Oprozomib
OPROZOMIB
PR-047
Proteasome Inhibitor ONX 0912

External Source Codes: 
CAS Registry Number 935888-69-0 (see NLM ChemIDplus info)
FDA UNII Code MZ37792Y8J
PDQ Closed Trial Search ID 674605 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 674605 (check for NCI PDQ open clinical trial info)
UMLS CUI C2716123

Other Properties:
Chemical_Formula C25H32N4O7S
code C91388
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91388&ns=NCI_Thesaurus

Mainbox Bottom