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MET Tyrosine Kinase Inhibitor EMD 1204831 (Code C91097)

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Terms & Properties

Preferred Name: MET Tyrosine Kinase Inhibitor EMD 1204831

Definition: An inhibitor of the receptor tyrosine kinase Met (hepatocyte growth factor receptor) with potential antineoplastic activity. MET inhibitor EMD 1204831 selectively binds to Met tyrosine kinase, thereby disrupting MET mediated signal transduction pathways. This may induce cell death in tumor cells overexpressing this kinase. MET is overexpressed or mutated in many tumor cell types, and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.

Display Name: MET Tyrosine Kinase Inhibitor EMD 1204831

Label: MET Tyrosine Kinase Inhibitor EMD 1204831

NCI Thesaurus Code: C91097 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL421483  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EMD 1204831
MET Tyrosine Kinase Inhibitor EMD 1204831

External Source Codes: 
NCI META CUI CL421483 (see NCI Metathesaurus info)
PDQ Closed Trial Search ID 672542 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 672542 (check for NCI PDQ open clinical trial info)

Other Properties:
code C91097
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91097&ns=NCI_Thesaurus

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