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Version: 14.12e (Release date: 2014-12-29-08:00)
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Ipamorelin (Code C81120)

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Terms & Properties

Preferred Name: Ipamorelin

Definition: A pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and a ghrelin mimetic with growth hormone (GH) releasing activity. Ipamorelin mimics ghrelin and binds to the ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain, thereby selectively stimulating the release of GH from the pituitary gland. This results in increased plasma GH levels, which would affect many biological processes. Besides its presence in the brain, GHSR can also be found in the gastrointestinal tract, heart, lung, liver, kidney, pancreas, adipose tissue and immune cells. Unlike other GH releasing peptides, ipamorelin only stimulates GH release in a manner very similar to that of growth hormone releasing hormone.

Display Name: Ipamorelin

Label: Ipamorelin

NCI Thesaurus Code: C81120 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
2-Methylalanyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenylalanyl-L-lysinamide
Aib-His-D-2-Nal-D-Phe-Lys-NH2
Ipamorelin
IPAMORELIN

External Source Codes: 
CAS Registry Number 170851-70-4 (see NLM ChemIDplus info)
FDA UNII Code Y9M3S784Z6
PDQ Closed Trial Search ID 719246 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 719246 (check for NCI PDQ open clinical trial info)
UMLS CUI C0757797

Other Properties:
Chemical_Formula C38H49N9O5
code C81120
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ipamorelin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C81120&ns=NCI_Thesaurus

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