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Version: 14.12e (Release date: 2014-12-29-08:00)
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Quinine (Code C794)

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Terms & Properties

Preferred Name: Quinine

Definition: A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

MeSH-2002 Definition: An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. (MSH2002_06_01)

Label: Quinine

NCI Thesaurus Code: C794 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
(-)-Quinine
QUIN
QUININE
Quinine

External Source Codes: 
CAS Registry Number 130-95-0 (see NLM ChemIDplus info)
FDA UNII Code A7V27PHC7A
ChEBI ID CHEBI:15854 (see ChEBI info)
NSC Code 192949 (see NCI DTP info)
PDQ Closed Trial Search ID 41253 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 41253 (check for NCI PDQ open clinical trial info)
UMLS CUI C0034417

Other Properties:
Chemical_Formula C20H24N2O2
code C794
Contributing_Source FDA
Legacy_Concept_Name Quinine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C794&ns=NCI_Thesaurus

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