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Version: 14.12e (Release date: 2014-12-29-08:00)
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IAP Inhibitor HGS1029 (Code C78484)

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Terms & Properties

Preferred Name: IAP Inhibitor HGS1029

Definition: The hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains.

Display Name: IAP Inhibitor HGS1029

Label: IAP Inhibitor HGS1029

NCI Thesaurus Code: C78484 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL387473  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AEG40826-2HCl
HGS1029
IAP Inhibitor HGS1029

External Source Codes: 
NCI META CUI CL387473 (see NCI Metathesaurus info)
PDQ Closed Trial Search ID 601033 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 601033 (check for NCI PDQ open clinical trial info)

Other Properties:
code C78484
Contributing_Source CTRP
Legacy_Concept_Name IAP_Inhibitor_HGS1029
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78484&ns=NCI_Thesaurus

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