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Version: 14.12e (Release date: 2014-12-29-08:00)
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Receptor Tyrosine Kinase Inhibitor R1530 (Code C71710)

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Terms & Properties

Preferred Name: Receptor Tyrosine Kinase Inhibitor R1530

Definition: A pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. Mitosis-angiogenesis inhibitor (MAI) R1530 inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta, FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis.

Display Name: Receptor Tyrosine Kinase Inhibitor R1530

Label: Receptor Tyrosine Kinase Inhibitor R1530

NCI Thesaurus Code: C71710 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL376137  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MAI R1530
Receptor Tyrosine Kinase Inhibitor R1530

External Source Codes: 
NCI META CUI CL376137 (see NCI Metathesaurus info)
PDQ Closed Trial Search ID 560180 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 560180 (check for NCI PDQ open clinical trial info)

Other Properties:
code C71710
Contributing_Source CTRP
Legacy_Concept_Name Mitosis_and_Apoptosis_Inhibitor_R1530
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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