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Version: 14.12e (Release date: 2014-12-29-08:00)
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Cationic Liposome-Encapsulated Paclitaxel (Code C69130)

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Terms & Properties

Preferred Name: Cationic Liposome-Encapsulated Paclitaxel

Definition: A cationic liposome preparation of paclitaxel with antineoplastic activity. Paclitaxel, the active ingredient in cationic liposome-encapsulated paclitaxel, binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis and cellular proliferation, and apoptosis. Cationic liposome encapsulation of paclitaxel allows the delivery of high doses of paclitaxel to target tissues while minimizing systemic toxicity. Tumor endothelial cells may preferentially bind and internalize cationic liposomes.

Label: Cationic Liposome-Encapsulated Paclitaxel

NCI Thesaurus Code: C69130 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
Cationic Liposome-Encapsulated Paclitaxel
EndoTAG-1
LipoPac
MBT-0206

External Source Codes: 
PDQ Closed Trial Search ID 543136 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 543136 (check for NCI PDQ open clinical trial info)
UMLS CUI C1722887

Other Properties:
code C69130
Legacy_Concept_Name Cationic_Liposome-Encapsulated_Paclitaxel
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69130&ns=NCI_Thesaurus

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