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Version: 14.12e (Release date: 2014-12-29-08:00)
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DNA Vector pPRA-PSM Vaccine (Code C67089)

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Terms & Properties

Preferred Name: DNA Vector pPRA-PSM Vaccine

Definition: A cancer vaccine consisting of a DNA plasmid encoding epitopes of the human preferential antigen of melanoma (PRAME) and the prostate specific membrane antigen (PSMA) with potential immunostimulating activity. Upon direct administration of this vaccine into lymph nodes, peptides expressed by DNA plasmid vector pPRA-PSM may activate the immune system, resulting in a cytotoxic T-lymphocyte (CTL) response against PRAME- and PSMA-expressing cells. PRAME and PSMA are tumor associated antigens upregulated in a number of cancer cell types. As part of the MKC1106-PP regimen exploiting the 'prime-boost strategy', this plasmid is responsible for priming the immune response and is used in conjunction with a peptide vaccine consisting of PRAME and PSMA that boosts the immune system against PRAME- and PSMA-expressing tumor cells.

Display Name: DNA Vector pPRA-PSM Vaccine

Label: DNA Vector pPRA-PSM Vaccine

NCI Thesaurus Code: C67089 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL376107  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DNA Plasmid Vector pPRA-PSM Vaccine
DNA Vector pPRA-PSM Vaccine
PRA-PSM-Expressing Plasmid

External Source Codes: 
NCI META CUI CL376107 (see NCI Metathesaurus info)
PDQ Closed Trial Search ID 536034 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 536034 (check for NCI PDQ open clinical trial info)

Other Properties:
code C67089
Contributing_Source CTRP
DesignNote Part of the MKC1106-PP regimen together with Synthetic Peptides E-PRA and E-PSM
Legacy_Concept_Name PRA-PSM-Expressing_Plasmid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67089&ns=NCI_Thesaurus

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