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Version: 14.12e (Release date: 2014-12-29-08:00)
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Cell Cycle Checkpoint/DNA Repair Antagonist IC83 (Code C67075)

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Terms & Properties

Preferred Name: Cell Cycle Checkpoint/DNA Repair Antagonist IC83

Definition: A proprietary agent with potential antineoplastic activity. IC83 appears to target cell cycle checkpoint/DNA repair enzymes, which are involved in the recognition and repair of damaged DNA and are overexpressed in many types of cancer cells. Inhibition of cell cycle checkpoint/DNA repair enzymes may enhance the cytotoxicity of DNA damaging agents and dissipate tumor cell resistance to chemotherapy and radiation therapy.

Display Name: Cell Cycle Checkpoint/DNA Repair Antagonist IC83

Label: Cell Cycle Checkpoint/DNA Repair Antagonist IC83

NCI Thesaurus Code: C67075 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
Cell Cycle Checkpoint/DNA Repair Antagonist IC83
IC83

External Source Codes: 
PDQ Closed Trial Search ID 536220 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 536220 (check for NCI PDQ open clinical trial info)
UMLS CUI C1881108

Other Properties:
code C67075
Contributing_Source CTRP
Legacy_Concept_Name IC83
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67075&ns=NCI_Thesaurus

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