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Version: 14.12e (Release date: 2014-12-29-08:00)
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Paclitaxel Vitamin E-Based Emulsion (Code C61079)

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Terms & Properties

Preferred Name: Paclitaxel Vitamin E-Based Emulsion

Definition: A cremophor-free, P-glycoprotein-inhibiting, vitamin E-based emulsion particle formulation of paclitaxel with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein B-cell Leukemia 2 (Bcl-2). The vitamin-E based emulsion allows bolus infusion without steroid premedication and may diminish hypersensitivity reactions. The tumor tissue may be passively targeted due to preferential deposition of emulsion particles while an emulsion formulation component inhibits the P-glycoprotein drug efflux pump.

Label: Paclitaxel Vitamin E-Based Emulsion

NCI Thesaurus Code: C61079 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
Paclitaxel Injectable Emulsion
Paclitaxel Vitamin E-Based Emulsion
PIE
S-8184
Tocosol

External Source Codes: 
PDQ Closed Trial Search ID 474798 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 474798 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541793

Other Properties:
code C61079
Legacy_Concept_Name Tocosol_Paclitaxel
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61079&ns=NCI_Thesaurus

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