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Version: 14.12e (Release date: 2014-12-29-08:00)
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Indium In 111 CHX-A DTPA Trastuzumab (Code C60766)

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Terms & Properties

Preferred Name: Indium In 111 CHX-A DTPA Trastuzumab

Definition: An indium In 111-labeled trastuzumab with potential use as an imaging agent. Indium In 111 CHX-A DTPA trastuzumab is chemically conjugated via a bifunctional metal chelator molecule, 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaacetic acid (CHX-A DTPA), a backbone-substituted derivative of DTPA. This agent may allow radioimmunolocalization of HER2-positive cells. Trastuzumab, a recombinant humanized monoclonal antibody that selectively binds with high affinity to the extracellular domain of human epidermal growth factor receptor 2 (HER2), may elicit an antibody-dependent cellular cytotoxicity (ADCC) against tumor cells that overexpress HER2.

NCI-GLOSS Definition: A substance being studied in the imaging of breast cancer and some other types of cancer. It is made by attaching a radioactive substance called indium 111 to the monoclonal antibody trastuzumab (Herceptin). Trastuzumab binds to the human growth factor receptor 2 (HER2/neu) on some breast cancer cells and on several other types of cancer cells. Indium In 111 CHX-A DTPA trastuzumab is a type of radioimmunoconjugate.

Display Name: Indium In 111 CHX-A DTPA Trastuzumab

Label: Indium In 111 CHX-A DTPA Trastuzumab

NCI Thesaurus Code: C60766 (Search for linked caDSR metadata)

NCI Metathesaurus CUI: CL360663  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
111In-CHX-A"-DTPA-Trastuzumab
Indium In 111 CHX-A DTPA Trastuzumab
indium In 111 CHX-A DTPA trastuzumab

External Source Codes: 
NCI META CUI CL360663 (see NCI Metathesaurus info)
NSC Code 740377 (see NCI DTP info)
PDQ Closed Trial Search ID 543723 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 543723 (check for NCI PDQ open clinical trial info)

Other Properties:
code C60766
Contributing_Source CTRP
Legacy_Concept_Name Indium-CHX-A_DTPA-Trastuzumab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C60766&ns=NCI_Thesaurus

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