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Version: 14.12e (Release date: 2014-12-29-08:00)
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Recombinant Interleukin-6 (Code C591)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant Interleukin-6

Definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-6 (IL-6) with antiapoptotic, proinflammatory, antiinflammatory, proproliferative and proangiogenic activities. IL-6 binds to its receptor (IL-6R), activating a receptor-CD130 receptor complex; the CD130 portion of the complex is a signal transduction protein that activates JAK kinases and Ras-mediated signaling pathways, which in turn activate downstream signaling pathways, resulting in the activation of various transcription factors (STAT, ELK-1, NF-IL-6, etc.) and gene transcription. The physiological effects of IL-6 are complex and varied and include hematopoietic, pyrogenic and thermogenic, proinflammatory, antiinflammatory, proproliferative (anti-apoptotic), and angiogenic effects.

NCI-GLOSS Definition: One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-6 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and also causes fever by affecting areas of the brain that control body temperature. Interleukin-6 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-6 is a type of cytokine.

Display Name: Recombinant Interleukin-6

Label: Recombinant Interleukin-6

NCI Thesaurus Code: C591 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
B-Cell Stimulatory Factor-2
B Cell Differentiation Factor 2
Hepatocyte Stimulating Factor
HPGF
HSF
Hybridoma Growth Factor
IFN Beta 2
IL-6
Interleukin-6
Myeloid Differentiation Inducing Protein
Plasmacytoma Growth Factor
Recombinant Interleukin-6
Sigosix

External Source Codes: 
PDQ Closed Trial Search ID 41474 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 41474 (check for NCI PDQ open clinical trial info)
UMLS CUI C1527132

Other Properties:
code C591
Contributing_Source CTRP
Legacy_Concept_Name Therapeutic_Interleukin-6
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C591&ns=NCI_Thesaurus

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