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Version: 14.12e (Release date: 2014-12-29-08:00)
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Adenovirus-mediated Human Interleukin-12 (Code C37515)

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Terms & Properties

Preferred Name: Adenovirus-mediated Human Interleukin-12

Definition: A replication incompetent adenovirus encoding human pro-inflammatory cytokine interleukin-12 (IL-12) (Ad.hIL-12), with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, the adenovirus selectively infects and replicates in tumor cells, which may result in tumor cell lysis. Synergistically, IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.

Label: Adenovirus-mediated Human Interleukin-12

NCI Thesaurus Code: C37515 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
Ad.hIL-12
Adenovirus-interleukin-12
Adenovirus-mediated Human Interleukin-12

External Source Codes: 
PDQ Closed Trial Search ID 436005 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 436005 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831638

Other Properties:
code C37515
Legacy_Concept_Name Adenovirus_Interleukin-12-Gene
Semantic_Type Therapeutic or Preventive Procedure

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C37515&ns=NCI_Thesaurus

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