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Version: 14.12e (Release date: 2014-12-29-08:00)
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Thioridazine Hydrochloride (Code C29498)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Thioridazine Hydrochloride

Definition: The hydrochloride salt form of thioridazine, a piperidine phenothiazine derivative and a dopamine antagonist with antipsychotic property. Thioridazine hydrochloride binds to mesolimbic postsynaptic dopamine receptor D2, thereby decreasing dopamine activity leading to decreased psychotic effects, such as hallucinations and delusions. In addition, this agent binds to serotonin 5-HT2 receptors, resulting in decreased serotonin activity.

Display Name: Thioridazine Hydrochloride

Label: Thioridazine Hydrochloride

NCI Thesaurus Code: C29498 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
Thioridazine Hydrochloride
THIORIDAZINE HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 130-61-0 (see NLM ChemIDplus info)
FDA UNII Code 4WCI67NK8M
ChEBI ID CHEBI:48566 (see ChEBI info)
NSC Code 186060 (see NCI DTP info)
PDQ Closed Trial Search ID 746026 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 746026 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700499

Other Properties:
Chemical_Formula C21H26N2S2.HCl
code C29498
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Thioridazine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29498&ns=NCI_Thesaurus

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