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Version: 14.12e (Release date: 2014-12-29-08:00)
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Carvedilol (Code C28906)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Carvedilol

Definition: A synthetic antihypertensive methoxyphenoxy- 2-propanol derivative with no intrinsic sympathomimetic activity, Carvedilol acts as a nonselective beta-adrenoceptor blocking agent (S(-) enantiomer) and as an alpha 1-adrenoceptor blocker (R(+) and S(-) enantiomers). Its acts more strongly on beta-receptors than on alpha 1-receptors, reduces peripheral vascular resistance by vasodilation, and prevents reflex tachycardia (beta-blockade) so that heart rate is either unchanged or decreased. Carvedilol also reduces renin release through beta-blockade. (NCI04)

NCI-GLOSS Definition: A drug used to treat high blood pressure and certain heart problems. It is also being studied in the prevention and treatment of side effects caused by some anticancer drugs. Coreg blocks certain receptors on nerve cells and causes blood vessels to dilate (widen). It is a type of antihypertensive agent and a type of antianginal agent.

Display Name: Carvedilol

Label: Carvedilol

NCI Thesaurus Code: C28906 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
Carvedilol
CARVEDILOL
Coreg

External Source Codes: 
CAS Registry Number 72956-09-3 (see NLM ChemIDplus info)
FDA UNII Code 0K47UL67F2
ChEBI ID CHEBI:3441 (see ChEBI info)
PDQ Closed Trial Search ID 700417 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 700417 (check for NCI PDQ open clinical trial info)
UMLS CUI C0719509

Other Properties:
Chemical_Formula C24H26N2O4
code C28906
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Carvedilol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28906&ns=NCI_Thesaurus

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