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Version: 14.12e (Release date: 2014-12-29-08:00)
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BIBX 1382 (Code C2539)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: BIBX 1382

Definition: A pyrimido-pyrimidine with antitumor activity. BIBX 1382 inhibits the intracellular tyrosine kinase domain of the Epidermal Growth Factor Receptor (EGFR) thus specifically reversing the aberrant enzymatic activity from overexpressed and constitutively activated EGFR, and subsequently inhibiting cell proliferation and inducing cell differentiation.

NCI-GLOSS Definition: A drug that may inhibit tumor cells from multiplying. It is being studied for its ability to treat cancer.

Label: BIBX 1382

NCI Thesaurus Code: C2539 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
BIBX1382
BIBX 1382

External Source Codes: 
PDQ Closed Trial Search ID 43568 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 43568 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879286

Other Properties:
code C2539
In_Clinical_Trial_For Solid Tumors.
Legacy_Concept_Name BIBX_1382
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2539&ns=NCI_Thesaurus

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