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Version: 14.12e (Release date: 2014-12-29-08:00)
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Interleukin-2 Liposome (Code C2373)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Interleukin-2 Liposome

Definition: A formulation in which liposomes are loaded with the cytokine interleukin-2 (IL-2). By activating cytotoxic T-lymphocytes, such as lymphokine-activated killer cells, and increasing levels of the cytotoxic cytokines interferon-gamma (IFN-gamma) and transforming growth factor-beta (TGF-beta), IL-2 may exhibit antitumoral activity. Liposomal formulations of IL-2 may promote entry of the cytokine into target tumor cells and may be used as an immunoadjuvant in cancer vaccine therapy. (NCI04)

Label: Interleukin-2 Liposome

NCI Thesaurus Code: C2373 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
Interleukin-2 Liposome
Liposome encapsulated interleukin-2

External Source Codes: 
PDQ Closed Trial Search ID 41486 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 41486 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281031

Other Properties:
code C2373
In_Clinical_Trial_For Refractory Cancer and Stage III Malignant Melanoma.
Legacy_Concept_Name Interleukin-2_Liposome
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2373&ns=NCI_Thesaurus

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