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Phenethyl Isothiocyanate (Code C2233)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Phenethyl Isothiocyanate

Definition: An isothiocyanate found in cruciferous vegetables with chemopreventive and potential antitumor activities. Although the mechanism of action is unclear, phenethyl Isothiocyanate (PEITC) was shown to induce apoptosis in tumor cells, possibly mediated through its metabolic intermediates, reactive oxygen species (ROS). PEITC also is able to activate ERK and JNK signal transduction, which in turn induces expression of stress-responsive genes. Specifically, this agent has been shown to reactivate gene expression of a detoxification enzyme, glutathione S-transferase that is silenced in prostate carcinoma.

NCI-GLOSS Definition: A substance being studied in the prevention of cancer. It is a naturally occurring compound found in some cruciferous vegetables.

Display Name: Phenethyl Isothiocyanate

Label: Phenethyl Isothiocyanate

NCI Thesaurus Code: C2233 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
(2-Isothiocyanatoethyl)benzene
2-Phenylethyl Isothiocyanate
PEITC
Phenethyl Isothiocyanate
PHENETHYL ISOTHIOCYANATE
Phenethyl isothiocyanate
phenethyl isothiocyanate

External Source Codes: 
CAS Registry Number 2257-09-2 (see NLM ChemIDplus info)
FDA UNII Code 6U7TFK75KV
ChEBI ID CHEBI:351346 (see ChEBI info)
NSC Code 87868 (see NCI DTP info)
PDQ Closed Trial Search ID 37977 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 37977 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 16921492 (see PubMed Primary Reference info)
UMLS CUI C0070558

Other Properties:
Chemical_Formula C9H9NS
code C2233
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Phenethyl_Isothiocyanate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2233&ns=NCI_Thesaurus

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