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Version: 14.12e (Release date: 2014-12-29-08:00)
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Indibulin (Code C2049)

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Terms & Properties

Preferred Name: Indibulin

Definition: A synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.

Label: Indibulin

NCI Thesaurus Code: C2049 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
D-24851
D 24851
INDIBULIN
Indibulin
N-(Pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glycoxylamide
ZIO-301

External Source Codes: 
CAS Registry Number 204205-90-3 (see NLM ChemIDplus info)
FDA UNII Code 80K4H2RB8P
PDQ Closed Trial Search ID 587341 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 587341 (check for NCI PDQ open clinical trial info)
UMLS CUI C1956330

Other Properties:
Chemical_Formula C22H16ClN3O2
code C2049
Contributing_Source FDA
Legacy_Concept_Name D_24851
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2049&ns=NCI_Thesaurus

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