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Human Combinatorial Antibody Library-based Monoclonal Antibody VAY736 (Code C116788)

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Terms & Properties

Preferred Name: Human Combinatorial Antibody Library-based Monoclonal Antibody VAY736

Definition: A fully human combinatorial antibody library (HuCAL)-derived monoclonal antibody targeting the B-cell-activating factor receptor (BAFF-R), with potential anti-inflammatory and antineoplastic activities. Upon administration of HuCAL-based antibody VAY736, the antibody targets and binds to BAFF-R, which inhibits both BAFF/BAFF-R interaction and BAFF-R-mediated signaling. This may decrease cell growth in tumor cells expressing BAFF-R. BAFF-R, also known as tumor necrosis factor receptor superfamily member 13C, is overexpressed in certain tumor cell types and autoimmune diseases. In cancer cells, BAFF-R plays a key role in B-cell proliferation and survival. VAY736 was developed using HuCAL technology.

Label: Human Combinatorial Antibody Library-based Monoclonal Antibody VAY736

NCI Thesaurus Code: C116788 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
HuCAL-based Antibody VAY736
Human Combinatorial Antibody Library-based Monoclonal Antibody VAY736
VAY736

External Source Codes: 
PDQ Closed Trial Search ID 762784 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 762784 (check for NCI PDQ open clinical trial info)

Other Properties:
code C116788
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C116788&ns=NCI_Thesaurus

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