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Version: 14.12e (Release date: 2014-12-29-08:00)
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Dolasetron Mesylate (Code C1153)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dolasetron Mesylate

Definition: An indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, dolasetron mesylate competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)

NCI-GLOSS Definition: A drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.

Display Name: Dolasetron Mesylate

Label: Dolasetron Mesylate

NCI Thesaurus Code: C1153 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
Anzemet
Dolasetron Mesylate
DOLASETRON MESYLATE
dolasetron mesylate
MDL 73,147EF

External Source Codes: 
CAS Registry Number 115956-13-3 (see NLM ChemIDplus info)
FDA UNII Code U3C8E5BWKR
PDQ Closed Trial Search ID 41354 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 41354 (check for NCI PDQ open clinical trial info)
UMLS CUI C0065818

Other Properties:
Accepted_Therapeutic_Use_For Nausea and vomiting prophylaxis, chemotherapy-induced and postoperative
Chemical_Formula C19H20N2O3.CH4O3S.H2O
code C1153
Contributing_Source CTRP
Contributing_Source FDA
In_Clinical_Trial_For Nausea, chemotherapy-induced
Legacy_Concept_Name Dolasetron_Mesylate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1153&ns=NCI_Thesaurus

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