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Version: 14.12e (Release date: 2014-12-29-08:00)
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Fludarabine Phosphate (Code C1102)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fludarabine Phosphate

Definition: The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

NCI-GLOSS Definition: A drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. It is also being studied in the treatment of other types of cancer. Fludara blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor.

Display Name: Fludarabine Phosphate

Label: Fludarabine Phosphate

NCI Thesaurus Code: C1102 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
2-F-ara-AMP
9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-
9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)
Beneflur
Fludara
Fludarabine-5'-Monophosphate
Fludarabine Phosphate
FLUDARABINE PHOSPHATE
fludarabine phosphate
Oforta
SH T 586

External Source Codes: 
CAS Registry Number 75607-67-9 (see NLM ChemIDplus info)
FDA UNII Code 1X9VK9O1SC
ChEBI ID CHEBI:63599 (see ChEBI info)
NSC Code 312887 (see NCI DTP info)
NSC Code 328002 (see NCI DTP info)
PDQ Closed Trial Search ID 39244 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 39244 (check for NCI PDQ open clinical trial info)
UMLS CUI C0060483

Other Properties:
Accepted_Therapeutic_Use_For Chronic Lymphocytic Leukemia
Chemical_Formula C10H13FN5O7P
code C1102
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fludarabine_Phosphate
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1102&ns=NCI_Thesaurus

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