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Version: 14.12e (Release date: 2014-12-29-08:00)
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Iproplatin (Code C1070)

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Terms & Properties

Preferred Name: Iproplatin

Definition: A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. (NCI04)

Label: Iproplatin

NCI Thesaurus Code: C1070 (Search for linked caDSR metadata)

Synonyms & Abbreviations: (see Synonym Details)
(OC-6-33)-dichlorodihydroxybis(2-propanamine)platinum
CHIP
Diisopropylammine-trans-dihydroxymalonatoplatinum(IV)
IPROPLATIN
Iproplatin
JM-9
Platinum, dichlorodihydroxybis(2-propanamine)-, (oc-6-33)-

External Source Codes: 
CAS Registry Number 62928-11-4 (see NLM ChemIDplus info)
CAS Registry Number 83291-20-7 (see NLM ChemIDplus info)
FDA UNII Code 5R9F9NE9Z2
NSC Code 256927 (see NCI DTP info)
PDQ Closed Trial Search ID 39183 (check for NCI PDQ closed clinical trial info)
PDQ Open Trial Search ID 39183 (check for NCI PDQ open clinical trial info)
UMLS CUI C0057856

Other Properties:
Chemical_Formula 2C3H9N.2Cl.Pt.2HO
code C1070
Contributing_Source FDA
Legacy_Concept_Name Iproplatin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1070&ns=NCI_Thesaurus

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